Related Experiment Video
Updated: Jun 21, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
Published on: March 31, 2016
Real-time neuronal homeostasis by coordinating VGSC intrinsic properties
Rongjing Ge1, Na Chen, Jin-Hui Wang
1Department of Physiology, Bengbu Medical College, Anhui, China.
Abstract:
Homeostasis of internal environment and cellular metabolism ensures cells' functions to be stable in living organisms. Cellular homeostasis is believed to be maintained via feedback or feedforward manners. We report a novel mechanism that maintains neuronal homeostasis through coordinating the intrinsic properties of single molecules concurrently. Spike encoding and sodium channel dynamics at cortical neurons were studied by patch-clamp recording. Voltage-gated sodium channels set refractory period and threshold potential toward different directions to stabilize the energetic barrier for firing sequential action potentials. This neuronal homeostasis is not affected by intracellular Ca(2+) signals and membrane potentials. Real-time homeostasis maintains precise and reliable neuronal encoding without any destabilization.
More Related Videos
05:01Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
Published on: September 20, 2024
09:07In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia
Published on: February 10, 2023
Related Concept Videos
Neural Regulation
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Homeostatic Imbalance
However, sometimes these feedback loops fail,...