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Updated: Jun 21, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Biomarkers in melanoma.

H Gogas¹, A M M Eggermont, A Hauschild

¹First Department of Medicine, Medical School, University of Athens, Greece. hgogas@hol.gr

Annals of Oncology : Official Journal of the European Society for Medical Oncology

|July 21, 2009

Summary

Identifying reliable melanoma biomarkers is crucial for predicting patient prognosis and treatment. This review highlights promising tissue and serum biomarkers, emphasizing the need for further clinical validation to improve melanoma classification and patient selection for therapies.

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Last Updated: Jun 21, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

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Published on: March 8, 2022

A 3D Organotypic Melanoma Spheroid Skin Model

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Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

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Published on: March 29, 2024

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Biomarkers correlate with tumor behavior and patient prognosis.
High-throughput techniques like DNA and RNA microarrays have identified potential melanoma biomarkers.
The clinical relevance of these biomarkers for melanoma progression and treatment selection requires further investigation.

Purpose of the Study:

To review predictive tissue and serum biomarkers for melanoma.
To discuss the molecular basis of established predictive biomarkers.
To identify promising novel biomarkers for future validation.

Main Methods:

Review of literature on melanoma biomarkers.
Analysis of data from DNA and RNA microarrays.
Discussion of established and investigational serum biomarkers.

Main Results:

Established tissue biomarkers include melanoma thickness, ulceration, and mitotic activity.
Tissue microarrays have identified novel potential biomarkers requiring independent validation.
Common serum biomarkers (lactate dehydrogenase, S100B, melanoma-inhibiting activity) and investigational markers (TA90IC, YKL-40) are discussed.

Conclusions:

Accurate classification of melanomas and selection of patients for targeted therapies remain significant challenges.
Further validation of identified biomarkers using prospective clinical data is essential.
Advancing biomarker research is critical for improving melanoma management and patient outcomes.