Related Experiment Video
Updated: Jun 21, 2026

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
Published on: March 15, 2019
ChIPing away at the genome: the new frontier travel guide
Jelena Aleksic1, Steven Russell
1Department of Genetics and Cambridge Systems Biology Centre, University of Cambridge, Downing Street, Cambridge, UK.
Abstract:
Chromatin immunoprecipitation (ChIP) is a powerful technique for obtaining in vivo data on protein-DNA binding, providing an invaluable tool for elucidating gene regulation at a molecular level. Combined with high-throughput methods such as microarrays (ChIP-array) and second generation sequencing (ChIP-seq), the technique is now commonly used for answering questions about protein binding on a genome-wide level. This review focuses on the use of microarrays and sequencing for ChIP studies, provides a critical comparison of the currently used platforms and an overview of the computational methods available, and offers recommendations for optimal use of the techniques in a research context.
Related Concept Videos
Genomics
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genome Size and the Evolution of New Genes
Genome Size and the Evolution of New Genes
Evolution of Microbial Genome
Sanger Sequencing

