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Related Experiment Video

Updated: Jun 21, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Cellularity and apparent diffusion coefficient in oligodendroglial tumours characterized by genotype.

Michael D Jenkinson¹, Daniel G du Plessis, Trevor S Smith

¹Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, L9 7LJ, UK. michael.jenkinson@liv.ac.uk

Journal of Neuro-Oncology

|July 21, 2009

Summary

Apparent diffusion coefficient (ADC) did not correlate with tumor cellularity in oligodendroglial tumors. This suggests differences in tumor biology or extracellular matrix composition influence ADC more than cell density.

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Area of Science:

Neuro-oncology
Radiology
Pathology

Background:

Apparent diffusion coefficient (ADC) quantifies water diffusion in tissues.
Previous studies show a negative correlation between ADC and glioma cellularity.
This relationship is not established for oligodendroglial tumors.

Purpose of the Study:

To investigate the correlation between ADC and tumor cellularity in oligodendroglial tumors.
To analyze this relationship in tumors characterized by their genotype (1p/19q status).

Main Methods:

ADC values (mean, min, max) were measured in 17 patients with oligodendroglial tumors (OII, OAII, OAIII).
Tumor cellularity was assessed via histopathology in serial biopsies.
1p/19q status was determined for all patients.

Main Results:

No significant linear correlation was found between ADC (mean, min, or max) and tumor cell density (mean, min, or max).
Tumor grade correlated with maximum cell density, but not with ADC.
No relationship was observed between cell density and 1p/19q genotype.

Conclusions:

Quantitative assessment of cellularity does not correlate with ADC in oligodendroglial tumors.
This finding may indicate unique biological characteristics of these tumors.
Extracellular matrix composition might play a more significant role in ADC than cellularity.