Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Alprostadil in Patients with Peripheral Arterial Occlusive Disease Fontaine Stage IV: Results of a Placebo Controlled Randomised Multicentre Trial (ESPECIAL).

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2017
Same author

Minor amputation does not negatively affect health-related quality of life as compared with conservative treatment in patients with a diabetic foot ulcer: An observational study.

Diabetes/metabolism research and reviews·2016
Same author

Diabetic foot syndrome.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2014
Same author

[Diabetic foot syndrome].

Deutsche medizinische Wochenschrift (1946)·2013
Same author

Importance of factors determining the low health-related quality of life in people presenting with a diabetic foot ulcer: the Eurodiale study.

Diabetic medicine : a journal of the British Diabetic Association·2013
Same author

Treatment of chronic wounds.

VASA. Zeitschrift fur Gefasskrankheiten·2012
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
See all related articles

Related Experiment Videos

[Diabetic foot syndrome].

H Lawall1, H Reike

  • 1Abteilung Angiologie/Diabetologie, SRH-Klinikum Karlsbad-Langensteinbach, Akad. Lehrkrankenhaus der Universität Heidelberg, Guttmannstrasse 1, Karlsbad, Germany. Holger.Lawall@kkl.srh.de

Der Internist
|July 21, 2009
PubMed
Summary
This summary is machine-generated.

Diabetic foot ulcers are common, leading to amputation and high mortality. Early expert assessment and interventions for infection, ischemia, and pressure are crucial for effective management and prevention.

Related Experiment Videos

Area of Science:

  • Diabetology
  • Vascular Surgery
  • Podiatry

Context:

  • Diabetic foot syndrome is a prevalent and disabling complication of diabetes mellitus.
  • High rates of morbidity, mortality, and ulcer recurrence persist despite current treatments.
  • The complex pathogenesis and variable clinical presentation necessitate specialized management approaches.

Purpose:

  • To outline the complex pathogenesis of diabetic foot syndrome.
  • To emphasize the need for early expert assessment and multidisciplinary intervention.
  • To detail essential treatment and preventive strategies for diabetic foot ulcers.

Summary:

  • Management requires addressing infection, peripheral ischemia, and pressure relief due to neuropathy and joint immobility.
  • Treatment involves wound debridement, stage-appropriate local wound care, and antibiotic therapy.
  • Prevention strategies include patient education, regular foot examinations, and appropriate footwear.

Impact:

  • Improved understanding of diabetic foot syndrome pathogenesis and management.
  • Reduced rates of lower extremity amputation and associated mortality/morbidity.
  • Enhanced strategies for preventing recurrence of diabetic foot ulcers through patient education and proper foot care.