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Updated: Jun 21, 2026
Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
Published on: July 16, 2019
Murine interferon-gamma inducible protein-10 (IP-10) secreted by Lactococcus lactis chemo-attracts human CD3+
Julio Villatoro-Hernandez1, Alma Yolanda Arce-Mendoza, Adrian G Rosas-Taraco
1Departamento de Histología, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño s/n, 64460, Monterrey, NL, Mexico.
Abstract:
Chemokines are members of the super family of cytokines necessary for leukocyte recruitment in tissues and lymphoid organs. The interferon-gamma inducible protein-10 (IP-10) chemo-attracts CXCR3-expressing cells, such as activated T lymphocytes and monocytes. We have genetically engineered a strain of Lactococcus lactis to secrete a biologically active murine IP-10 that interacts with human CXCR3, its homolog receptor, and chemo-attracts human CD3+ T lymphocytes.
