Related Experiment Video
Updated: Jun 21, 2026

Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
Immunity to avian influenza A viruses
P C Doherty1, L E Brown, A Kelso
1Department of Microbiology and immunology, The University of Melbourne, Vic 3010, Australia. pcd@unimelb.edu.au
Abstract:
While the basic principles of immunity to the influenza A viruses are probably similar for all vertebrates, detailed understanding is based largely on experiments in laboratory mice. Elements of the innate response limit early virus replication, although high pathogenicity strains can trigger effusive cytokine/chemokine production and lethal shock. Virus clearance is normally mediated via CD8+ effector T cells but, in their absence, the class-switched antibody response can ultimately achieve the same goal. Protection against reinfection is optimally provided by antibody (IgG and IgA) specific for the homologous viral haemagglutinin, and priming against the neuraminidase and the low abundance, conserved M2 protein can also have an effect. Influenza virus-specific plasma cells and CD8+ T cells persist in the long term and the recall of the CD8+ T cell response can lead to earlier virus clearance. The characteristics of the aging immune system and possible, novel vaccine strategies are also considered.
More Related Videos
08:46Rapid Diagnosis of Avian Influenza Virus in Wild Birds: Use of a Portable rRT-PCR and Freeze-dried Reagents in the Field
Published on: August 2, 2011
07:15Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity
Published on: November 22, 2021
Related Concept Videos
Viral Recombination
Influenza
Leaky Scanning
Vaccinations
Inhibitors Of Virion Release
Viral Mutations