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Molecularly imprinted polymers--tyrosinase mimics
S A Piletsky1, I A Nicholls, M I Rozhko
1Institute of Bioscience and Technology, Cranfield University, UK.
Abstract:
Synthetic polymers mimicking the enzyme tyrosinase have been prepared by the molecular imprinting of a complex between Cu (II) and catechol and ethyl ester of urocanic acid in an ethylene glycol dimethacrylate copolymer. Optimised polymer systems demonstrated catalysis, Michaelis-Menten kinetics and competitive inhibition similar to those of mushroom tyrosinase. The polymers benefited from superior chemical and mechanical stability in comparison with natural enzyme.
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