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Antimicrobial resistance among and therapeutic options against gram-negative pathogens

James J Rahal1

  • 1Infectious Disease Section,New York Hospital Queens, 56-45 Main St., Flushing, NY 11355, USA. jjr9002@nyp.org

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 22, 2009
PubMed

Insights

Increasing antimicrobial resistance in gram-negative bacterial pathogens necessitates new treatments. Doripenem, a novel carbapenem, shows significant activity against challenging pathogens like Pseudomonas aeruginosa, offering a potential new option for serious infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Gram-negative bacterial infections are common and rising resistance to antimicrobials is a major concern.
  • Beta-lactamase-mediated resistance is a significant driver of treatment failure.
  • Enterobacteriaceae and nonfermenting gram-negative organisms exhibit increasing high-level resistance.

Purpose of the Study:

  • To evaluate the efficacy of doripenem against difficult-to-treat gram-negative bacterial pathogens.
  • To compare doripenem's activity with other carbapenems.

Main Methods:

  • The study assessed doripenem's in vitro activity against various gram-negative pathogens.
  • Comparative analysis was performed against other carbapenems.

Main Results:

  • Doripenem demonstrates potent activity against Pseudomonas aeruginosa, surpassing other carbapenems.
  • Activity against Acinetobacter species and most Enterobacteriaceae is equivalent to existing carbapenems.

Conclusions:

  • Doripenem exhibits strong coverage against challenging gram-negative pathogens.
  • It represents a valuable therapeutic option, alone or in combination, for serious gram-negative infections.

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