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Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Preparation and properties of a novel biodegradable polyester elastomer with functional groups
Quan-Yong Liu1, Si-Zhu Wu, Tian-Wei Tan
1Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.
Journal of Biomaterials Science. Polymer Edition
|July 22, 2009
Summary
A new biodegradable poly(sebacate-glycerol-citrate) (PGSC) elastomer was developed. This functional material offers tunable mechanical and degradation properties for medical applications like anti-conglutination films and drug delivery.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
Background:
- Biodegradable polymers are crucial for biomedical applications.
- Developing functional elastomers with tunable properties remains a challenge.
Purpose of the Study:
- To synthesize and characterize a novel biodegradable poly(sebacate-glycerol-citrate) (PGSC) elastomer.
- To investigate the influence of thermal curing time on PGSC properties.
- To explore potential biomedical applications of PGSC.
Main Methods:
- Synthesis of poly(glycerol-sebacate) (PGS) pre-polymers.
- Preparation of PGSC elastomers via thermal curing.
- Characterization using FT-IR, DSC, swelling tests, tensile tests, water contact angle, water absorption, and in vitro degradation.
Main Results:
- PGSC elastomers with remaining hydroxyl groups were successfully prepared.
- Hydroxyl groups provide functionality for surface modification.
- Mechanical and biodegradable properties were tunable by controlling thermal curing time.
Conclusions:
- PGSC elastomers exhibit promising properties for biomedical applications.
- Potential uses include anti-conglutination films, guided tissue regeneration membranes, and drug-delivery matrices.
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