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11:19
Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
Published on: February 25, 2011
The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery
Chen Davidovich1, Matthew Belousoff, Anat Bashan
1The Department of Structural Biology, Weizmann Institute, Rehovot, Israel.
Research in Microbiology
|July 22, 2009
Abstract:
Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome's active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization.
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