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Updated: Jun 21, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Endothelial dysfunction and aging: an update.

María Dolores Herrera¹, Carmen Mingorance, Rosalía Rodríguez-Rodríguez

¹Department of Pharmacology, Faculty of Pharmacy, University of Seville, C/Profesor García González 2, 41012 Seville, Spain. mdherrera@us.es

Ageing Research Reviews

|July 22, 2009

Summary

Aging impairs endothelial function, a key factor in cardiovascular diseases like atherosclerosis and hypertension. This decline involves reduced nitric oxide (NO) and increased vasoconstrictors, driven by oxidative stress and inflammation.

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Last Updated: Jun 21, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Published on: June 16, 2014

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

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Published on: June 3, 2019

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Area of Science:

Cardiovascular Science
Aging Research
Endothelial Biology

Background:

Aging is a primary risk factor for cardiovascular diseases, including atherosclerosis and hypertension.
A common mechanism is the progressive decline in endothelial function during aging.
This dysfunction involves an imbalance in endothelium-derived vasodilator and vasoconstrictor substances.

Purpose of the Study:

To review the pathophysiological mechanisms underlying age-related endothelial dysfunction.
To explore the roles of oxidative stress, inflammation, and cellular senescence.
To discuss the impact of genetic factors on endothelial function decline.

Main Methods:

Literature review of aging and cardiovascular disease.
Analysis of mechanisms affecting endothelial function.
Focus on nitric oxide (NO) bioavailability and vasoconstrictor factors.

Main Results:

Aging leads to reduced nitric oxide (NO) bioavailability.
Increased production of cyclooxygenase (COX)-derived vasoconstrictor factors is observed.
Oxidative stress and reactive nitrogen species contribute to endothelial dysfunction.

Conclusions:

Endothelial dysfunction is a hallmark of aging, contributing to cardiovascular disease.
Mechanisms include oxidative stress, pro-inflammatory cytokines, endothelial cell senescence, and genetic factors.
Understanding these mechanisms is crucial for mitigating age-related cardiovascular risks.