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[Testicular carcinoma and sarcoid-like necrotizing granulomatosis]
Béma Coulibaly1, Cécile de Biasi, Olivier Gisserot
1Service d'anatomie pathologique et de neuropathologie, CHU Timone, 13385 Marseille cedex 05, France. bema_coulibaly@yahoo.fr
Abstract:
A 35-year-old man with a stage I non-seminomatous germ-cell tumor of the right testis was treated with a simple orchidectomy. Sixty-seven months later, the patient who was on clinical follow-up, has presented five bilateral lung nodules on computed-tomography scan. Additional staging showed no other abnormalities. Lung biopsy of two nodules was performed during a videothoracoscopy and the histologic examination revealed a sarcoidosis-like necrotizing granulomatosis. The coexistence of non-caseating granulomas and testis carcinoma showed an increase during the last two decades. The immunopathogenesis of sarcoid formation in malignant tumours is still unknown. During follow-up of patients with testicular carcinomas, the presence of lung nodules requires a histologic examination and sarcoidosis should be considered as differential diagnosis.
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