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Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
Cervical dysplasia in Nigerian women infected with HIV
Patricia A Agaba1, Thomas D Thacher, Chinedu C Ekwempu
1AIDS Prevention Initiative Nigeria Plus, Jos University Teaching Hospital, Jos, Nigeria. ellagaba@yahoo.com
Objective:
To determine the prevalence of and risk factors for cervical dysplasia in HIV-positive women receiving care at the Jos University Teaching Hospital in Nigeria.
Methods:
A total of 369 HIV-positive women had cervical cytology performed; HIV-1 RNA viral load and CD4 counts were measured.
Results:
Of 369 participants, cervical dysplasia was present in 107 (29.0%) women. However, cervical cytology was abnormal in 252 (68.3%). Among those with abnormal cytology, 145 (57.5%) women had ASCUS, 56 (22.2%) had LSIL, and 51 (20.2%) had HSIL. Median CD4 lymphocyte count was lower in women with dysplasia compared with those without (142 vs 170 cells/mm(3); P=0.04), while median HIV RNA viral load was higher in women with dysplasia (101781 vs 77479 copies/mL; P=0.002). Low CD4 count (<200 cells/mm(3)) and evidence of HPV infection were significantly associated with cervical dysplasia.
Conclusion:
A high prevalence of cervical dysplasia was found among HIV-positive Nigerian women, which was associated with increased immune suppression.
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