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[Expression of annexin V in decidua tissues of preeclampsia patients]
Ya-Ling Feng1, Chang-Ju Zhou, Min Xue
1Department of Obstetrics and Gynecology, Third Affiliated Hospital of Xiangya Medical College, Central South University, Changsha 410013, China. fengyl523@yahoo.com.cn
Objective:
To investigate the expression of annexin V in the decidua tissues of preeclampsia patients and explore its clinical significance.
Methods:
Real-time PCR, Western blotting and immunohistochemistry were employed to detect the mRNA and protein expressions of annexin V in the deciduas from 35 normal pregnant women at full term, 38 early onset severe preeclampsia patients and 33 late onset severe preeclampsia patients.
Results:
Annexin V was found on the cell membrane and in the cytoplasm of the decidual cells and stroma. Both the mRNA and protein of annexin V expressions in the decidua tissues were significantly different between normal pregnancy group and early or late onset severe preeclampsia group (P<0.05), being the highest in normal pregnancy group and the lowest in early onset severe preeclampsia group.
Conclusion:
The low expression of annexin V in the deciduas might participate in the hypercoagulability state in preeclampsia patients.
