Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

Blocking TNF-alpha attenuates aneurysm formation in a murine model.

Wanfen Xiong¹, Jason MacTaggart, Rebecca Knispel

¹Department of Surgery, University of Nebraska Medical Center, Omaha,NE 68198, USA.

Journal of Immunology (Baltimore, Md. : 1950)

|July 22, 2009

Summary

Tumor necrosis factor-alpha (TNF-alpha) drives abdominal aortic aneurysm (AAA) formation by promoting inflammation and matrix degradation. Blocking TNF-alpha with infliximab effectively prevented AAA development in a mouse model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Orally bioavailable CB<sub>2</sub> receptor agonists attenuate neuroinflammation and stabilize the blood-brain barrier.

Research square·2026

Same author

Total Hip Arthroplasty Following Failed Cephalomedullary Nailing: An Analysis of Outcomes and Complications Associated With Failures.

The Journal of arthroplasty·2026

Same author

Tibial Post Fracture in Posterior-Stabilized Total Knee Arthroplasty: Is Fatigue Alone the Culprit?

The Journal of arthroplasty·2026

Same author

Multimodal intra-subject characterization of abdominal aortic aneurysm pathophysiology: a case study.

Biomechanics and modeling in mechanobiology·2026

Same author

P2X7R Signaling and Differential Regulation of Neuroinflammatory and Behavior Responses in Male and Female Mice During Chronic Ethanol Exposure.

International journal of molecular sciences·2026

Same author

Biomechanical Characterization of Porcine Lower Limb Arteries for Preclinical Evaluation of Peripheral Vascular Devices.

Annals of biomedical engineering·2026

Area of Science:

Cardiovascular Biology
Immunology
Molecular Medicine

Background:

Abdominal aortic aneurysm (AAA) involves inflammation and matrix destruction.
Macrophages and T lymphocytes infiltrate AAA tissue.
Tumor necrosis factor-alpha (TNF-alpha) is elevated in AAA patients.

Purpose of the Study:

To investigate the role of TNF-alpha in AAA pathogenesis.
To evaluate TNF-alpha antagonism as a therapeutic strategy for AAA.

Main Methods:

Utilized a murine model of AAA.
Assessed TNF-alpha levels (mRNA and protein) in aneurysm tissue.
Examined AAA formation in TNF-alpha deficient mice.
Investigated the effect of infliximab (a TNF-alpha antagonist) on AAA growth and associated molecular changes.

More Related Videos

A Murine Model of Carotid Aneurysm Formation

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

Related Experiment Videos

Last Updated: Jun 21, 2026

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

A Murine Model of Carotid Aneurysm Formation

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

Main Results:

TNF-alpha levels were significantly increased in AAA tissue.
Mice lacking TNF-alpha were resistant to AAA formation.
TNF-alpha deficiency reduced macrophage infiltration and matrix metalloproteinase (MMP) 2 and MMP-9 expression.
Infliximab treatment inhibited AAA growth, elastic fiber disruption, macrophage infiltration, and MMP expression.

Conclusions:

TNF-alpha plays a critical role in AAA development by regulating inflammation and matrix remodeling.
Targeting TNF-alpha with antagonists like infliximab shows therapeutic potential for AAA treatment.