Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondria: structure and function.

H S Sherratt1

  • 1Department of Pharmacological Sciences, University of Newcastle upon Tyne, UK.

Revue Neurologique
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enzyme studies in combined carboxylase deficiency.

Annals of the New York Academy of Sciences·2015
Same author

Control of mitochondrial beta-oxidation at the levels of [NAD+]/[NADH] and CoA acylation.

Advances in experimental medicine and biology·2000
Same author

Methylene blue and fatal encephalopathy from ackee fruit poisoning.

Lancet (London, England)·1999
Same author

Etomoxir, sodium 2-[6-(4-chlorophenoxy)hexyl] oxirane-2-carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes.

FEBS letters·1997
Same author

Introduction: the regulation of fatty acid oxidation in cells.

Biochemical Society transactions·1994
Same author

Regulation of fatty acid oxidation in cells.

Biochemical Society transactions·1994

Mitochondria generate cellular energy (ATP) through oxidative phosphorylation, a process dependent on their structural integrity and the electron transport chain. Mitochondrial DNA plays a role in coding for essential protein subunits.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Genetics

Background:

  • Mitochondria are central to ATP synthesis in aerobic cells.
  • They possess a double membrane structure housing key metabolic enzymes and the electron transport chain.
  • Oxidative phosphorylation, the primary ATP production pathway, relies on mitochondrial structural integrity.

Purpose of the Study:

  • To elucidate the structural and functional aspects of mitochondria in ATP synthesis.
  • To describe the components and processes of the electron transport chain and oxidative phosphorylation.
  • To highlight the role of mitochondrial DNA (mtDNA) and protein import in mitochondrial function.

Main Methods:

  • Review of established biochemical and cellular processes.
  • Analysis of the electron transport chain's mechanism and proton motive force generation.

Related Experiment Videos

  • Description of mitochondrial genetic system and protein synthesis.

    • Main Results:

    • Mitochondria utilize metabolic fuels and oxygen for ATP production via oxidative phosphorylation.
    • The electron transport chain (complexes I-IV) pumps protons, creating a gradient that drives ATP synthase.
    • Mitochondrial DNA encodes some subunits, while others are synthesized in the cytosol and imported.

    Conclusions:

    • Mitochondrial structure is essential for efficient ATP synthesis.
    • The precise stoichiometry of proton pumping and ATP yield requires further investigation.
    • Mitochondria exhibit maternal inheritance and possess their own genetic material (mtDNA).