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[Anti-angiogenic drugs]

Yasufumi Sato1

  • 1Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 22, 2009
PubMed

Insights

Angiogenesis, the formation of new blood vessels, is crucial in cancer. Anti-angiogenic drugs targeting VEGF, like bevacizumab, offer effective cancer treatment by inhibiting tumor blood vessel growth.

Area of Science:

  • Oncology and Molecular Biology

Context:

  • Angiogenesis, the formation of new blood vessels, is a critical physiological process implicated in various pathological conditions, notably cancer.
  • The inhibition of tumor angiogenesis has been a long-standing therapeutic objective in cancer research.

Purpose:

  • To review the development and clinical significance of anti-angiogenic therapies targeting VEGF-mediated signals in cancer treatment.

Summary:

  • Bevacizumab, a monoclonal antibody neutralizing VEGF, was the first anti-angiogenic drug, validating the clinical benefit of inhibiting tumor angiogenesis.
  • Subsequent development has focused on various drugs targeting VEGF-mediated pathways to control tumor angiogenesis.
  • Anti-angiogenic therapy represents a significant advancement in clinical cancer treatment.

Impact:

  • The advent of anti-angiogenic drugs has transformed cancer treatment paradigms.
  • Targeting tumor angiogenesis offers a novel strategy for managing and treating various cancers.
  • This therapeutic approach underscores the importance of understanding tumor microenvironment interactions.

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