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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

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Dehydroepiandrosterone sulfate and cognitive function in the elderly: The InCHIANTI Study.

G Valenti¹, L Ferrucci, F Lauretani

¹Department of Internal Medicine and Medical Sciences, Section of Geriatrics, University of Parma, Parma 43100, Italy. giorgiovalenti@libero.it.

Journal of Endocrinological Investigation

|July 22, 2009

Summary

Dehydroepiandrosterone sulfate (DHEAS) levels decline with age and are linked to cognitive function. Lower DHEAS predicts faster cognitive decline in older adults, highlighting its importance for brain health.

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Published on: January 24, 2020

Area of Science:

Gerontology
Neuroscience
Endocrinology

Background:

Dehydroepiandrosterone sulfate (DHEAS) levels naturally decrease with aging.
This decline is potentially linked to age-related physiological impairments, including cognitive dysfunction.
Existing research on the DHEAS-cognition relationship in older adults is limited.

Purpose of the Study:

To investigate the association between DHEAS levels and the presence and progression of cognitive decline.
To examine the relationship between baseline DHEAS and cognitive function measured by the Mini Mental State Examination (MMSE) over a 3-year period in older adults.

Main Methods:

Analysis of data from 755 participants (aged >=65 years) in the InCHIANTI Study with baseline and 3-year follow-up MMSE scores and DHEAS levels.
Statistical modeling (backward selection) was used to identify independent factors associated with MMSE and DHEAS.
Analysis focused on participants with a baseline MMSE score of 21 or higher.

Main Results:

Significant age-related declines in both DHEAS levels and MMSE scores were observed over the 3-year follow-up.
Baseline DHEAS levels showed a significant positive association with MMSE scores, independent of age and other confounders.
Lower baseline DHEAS levels were predictive of a greater decline in MMSE scores over time.

Conclusions:

A significant positive association exists between DHEAS levels and cognitive function as assessed by the MMSE.
Low DHEAS levels emerge as a predictor of accelerated cognitive decline in older men and women.
These findings underscore the potential role of DHEAS in maintaining cognitive health during aging.