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Infections caused by Propionibacterium species
1Department of Pediatrics, National Naval Medical Center, Bethesda, Maryland.
Reviews of Infectious Diseases
|September 1, 1991
Summary
Propionibacterium species, including Propionibacterium acnes, are rarely the cause of serious infections. However, when infections occur, they are often associated with underlying conditions and may require surgical intervention alongside antimicrobial therapy.
Area of Science:
- Medical Microbiology
- Infectious Diseases
Background:
- Propionibacterium species, particularly Propionibacterium acnes, are common skin commensals.
- Their role in human infections is often underestimated, frequently being dismissed as contaminants.
Purpose of the Study:
- To investigate the incidence and clinical significance of Propionibacterium species infections.
- To identify common infection sites, predisposing factors, and treatment outcomes.
Main Methods:
- Retrospective analysis of anaerobic bacterial isolates over a 10-year period.
- Identification of Propionibacterium species from 3,971 clinical specimens.
- Review of patient records for clinical data, predisposing conditions, and treatment.
Main Results:
- Out of 816 Propionibacterium isolates, 94 (12%) in 92 patients were linked to infections.
- Common infection sites included blood, central nervous system, lymph glands, abscesses, joints, and wounds.
- Predisposing factors were present in 70% of patients, notably foreign bodies, diabetes, and previous surgery.
- Five patients (5%) experienced fatal outcomes.
Conclusions:
- Propionibacterium species, though infrequent pathogens, can cause severe infections.
- Management often involves a combination of antimicrobial therapy and surgical intervention.
- Awareness of Propionibacterium's pathogenic potential is crucial for accurate diagnosis and treatment.