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Updated: Jun 21, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Early neovascular bridging of choroidal neovascularization after ranibizumab treatment
Juan Reche-Frutos1, Cristina Calvo-Gonzalez, Juan Donate-Lopez
1Hospital Clínico Universitario San Carlos, Calle Profesor Martín Lagos s/n, Madrid, Spain. echejuan@yahoo.es
Background:
To report three cases of early choroidal neovascularization (CNV) bridging after ranibizumab treatment.
Methods:
Three patients with two separated foci of CNV secondary to age-related macular degeneration (ARMD), pathologic myopia and multifocal choroiditis were treated with monthly injections of ranibizumab por a period of 3 months.
Results:
All three cases showed early coalescence across the fovea of the two neovascular foci, already 1 month after the first ranibizumab injection. Best-corrected visual acuity (BCVA) decreased in the three cases more than 20 letters due to early foveal involvement.
Conclusions:
Two different foci of CNV show a great tendency to decrease patients' vision because of neovascular bridging with foveal implication.
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