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Glioblastoma with primitive neuroectodermal tumor-like features: case report.
Nilüfer Onak Kandemir1, Burak Bahadir, Sanser Gül
1Zonguldak Karaelmas University, School of Medicine, Department of Pathology, Zonguldak, Turkey. niluferkandemir@yahoo.com
Turkish Neurosurgery
|July 22, 2009
Summary
This study reports a rare case of glioblastoma with a primitive neuroectodermal tumor-like component in an adult female. This rare glioblastoma subtype showed no recurrence after treatment.
Area of Science:
- Neuro-oncology
- Pathology
- Cancer Research
Background:
- Glioblastoma (GB) is the most aggressive primary brain tumor in adults.
- Uncommon presentations of glioblastoma, such as areas with small cell morphology and neural immunophenotype, pose diagnostic challenges.
Observation:
- A 61-year-old female presented with a frontotemporal tumor, radiologically consistent with glioblastoma.
- Histopathological examination revealed a biphasic tumor: a predominant classic glioblastoma component and an undifferentiated, small cell component with a neuronal immunophenotype.
Findings:
- The tumor was diagnosed as glioblastoma with a primitive neuroectodermal tumor-like component.
- The patient received adjuvant radiotherapy and showed no recurrence at 9-month follow-up.
Implications:
- The histogenesis and prognostic impact of neuronal differentiation in glial tumors require further investigation.
- Documenting such rare components is crucial for building databases for future research on glioblastoma heterogeneity.
