Related Experiment Video
Updated: Jun 21, 2026
11:54
Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
[BK virus and renal transplantation]
Hang Liu1, Yi Shi, Chao-yang Li
1Department of Transplantation, Tianjin First Center Hospital, Tianjin 300192, China. liuhang66@yahoo.com.cn
Summary
BK virus (BKV) reactivation is common in kidney transplant patients, potentially causing BKV-associated nephropathy (BKVAN) and graft failure. This review covers BKVAN
Area of Science:
- Virology: Focuses on BK virus (BKV), a polyomavirus.
- Immunology: Addresses BKV reactivation in immunocompromised individuals.
Context:
- BK virus (BKV) infection is widespread but typically latent in healthy populations.
- Renal transplant recipients face a significant risk of BKV reactivation (10%-68%).
Purpose:
- To summarize the mechanisms of BK virus (BKV) reactivation.
- To review risk factors, pathology, diagnosis, and treatment of BKV-associated nephropathy (BKVAN).
Summary:
- BK virus-associated nephropathy (BKVAN) affects 1%-7% of kidney transplant recipients.
- Half of BKVAN patients experience kidney graft failure.
- This paper details BKV reactivation, BKVAN, and its management.
Impact:
- Highlights the critical threat of BKVAN to kidney transplant success.
- Informs clinical practice regarding BKVAN prevention and treatment.
- Underscores the importance of monitoring BKV in transplant recipients.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...