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Related Experiment Video

Updated: Jun 21, 2026

Extraction and Analysis of Cortisol from Human and Monkey Hair

Extraction and Analysis of Cortisol from Human and Monkey Hair

Published on: January 24, 2014

Cynomolgus monkey CYPs: a comparison with human CYPs.

K Iwasaki¹, Y Uno

¹Business Development Department, Shin Nippon Biomedical Laboratories Ltd, Osaka, Japan. iwasaki-kazuhide@snbl.co.jp

Xenobiotica; the Fate of Foreign Compounds in Biological Systems

|July 23, 2009

Summary

Cynomolgus monkey cytochrome P450 (CYP) enzymes show high similarity to human drug-metabolizing CYPs. This suggests their utility in preclinical drug development and understanding human drug metabolism.

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Area of Science:

Biochemistry
Pharmacology
Drug Metabolism

Background:

Cytochromes P450 (CYPs) are crucial for drug metabolism in humans.
Cynomolgus monkeys are frequently used preclinical models for drug development.

Purpose of the Study:

To characterize cynomolgus monkey CYPs involved in drug metabolism.
To compare their sequences and functions with human CYPs.

Main Methods:

Sequence homology analysis (cDNA and amino acid) of cynomolgus monkey CYPs.
Enzyme activity assays for typical CYP substrates.

Main Results:

Eleven cynomolgus monkey CYPs (CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, CYP3A subfamilies) showed >90% homology to human counterparts.
These eleven CYPs catalyzed reactions typical of their human orthologs.
A unique cynomolgus monkey CYP2C76 exhibited lower homology (~70%) and low activity with CYP2C substrates, not found in humans.

Conclusions:

Cynomolgus monkey CYPs are highly similar to key human drug-metabolizing enzymes.
These findings support the use of cynomolgus monkeys for studying human drug metabolism and safety.