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Related Concept Videos

RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

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Updated: Jun 21, 2026

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
11:32

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

The RNA structure alignment ontology.

James W Brown, Amanda Birmingham, Paul E Griffiths

    RNA (New York, N.Y.)
    |July 23, 2009
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces an RNA alignment ontology to improve RNA sequence alignments. It addresses limitations of traditional 2D methods, enabling better integration of structural and experimental data for RNA analysis.

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    RNA Secondary Structure Prediction Using High-throughput SHAPE
    13:42

    RNA Secondary Structure Prediction Using High-throughput SHAPE

    Published on: May 31, 2013

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Structural Biology

    Background:

    • Multiple sequence alignments are crucial for understanding biological macromolecules like RNA.
    • Traditional 2D RNA sequence alignments face limitations in representing biological relationships and scalability with high-throughput data.

    Discussion:

    • The study highlights the unrealistic nucleotide-by-nucleotide correspondence requirement in current RNA alignments.
    • The rapid increase in sequencing data exacerbates the unmanageability of traditional 2D alignment formats.
    • Explicit annotation of relationships within alignments is necessary to overcome these shortcomings.

    Key Insights:

    • An RNA alignment ontology based on the concept of 'correspondence' is proposed.
    • This ontology facilitates the development of novel RNA data representations and software tools.
    • It enables better integration of sequence, secondary, and 3D structural information.

    Outlook:

    • The new ontology aims to resolve scalability issues in RNA sequence alignments.
    • It will lead to more accurate and exploitable RNA alignments by integrating diverse data types.
    • This approach supports advanced analysis of RNA structures, functions, and evolutionary histories.