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Updated: Jun 21, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Maternal immunoglobulin E and childhood leukemia.

Jeffrey S Chang¹, Patricia A Buffler, Catherine Metayer

¹Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, CA 94143-1215, USA. c_jeffrey@hotmail.com

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

|July 23, 2009

Summary

Maternal elevated immunoglobulin E (IgE) levels are linked to a higher risk of childhood leukemia, including acute lymphoblastic leukemia (ALL). This suggests maternal immune status may influence childhood cancer development.

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Area of Science:

Immunology
Pediatric Oncology
Epidemiology

Background:

Childhood leukemia, especially acute lymphoblastic leukemia (ALL), is suspected to involve immune dysregulation due to early-life microbial exposures.
Allergy research indicates maternal immune status can impact a child's immune system development.

Purpose of the Study:

To investigate the association between maternal immunoglobulin E (IgE) levels and childhood leukemia risk.
To explore if maternal immune status influences the development of childhood leukemia.

Main Methods:

Serum total and specific IgE (respiratory and food) were measured in mothers of 352 children (<8 years) from the Northern California Childhood Leukemia Study.
Unconditional logistic regression was used to calculate odds ratios, adjusting for child's age, sex, race/ethnicity, and household income.

Main Results:

Elevated maternal serum total IgE showed a positive association with childhood leukemia and ALL, particularly in Hispanic children.
Positive associations were also found between childhood leukemia/ALL and maternal respiratory or food IgE status.

Conclusions:

Maternal immune function, indicated by IgE levels, may play a significant role in the origins of childhood leukemia.
Further research is needed to confirm these findings and elucidate underlying mechanisms.