Related Experiment Video
Updated: Jun 21, 2026
10:35
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
Published on: September 20, 2015
T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke
M L Donswijk1, P S Jones, J V Guadagno
1Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Cerebrovascular Diseases (Basel, Switzerland)
|July 23, 2009
Summary
T2*-weighted MRI was investigated as a marker for high oxygen extraction fraction (OEF) in acute stroke patients. This study found no significant relationship between T2* signal and OEF, suggesting T2*-weighted MRI is not sensitive to high OEF in this context.
Area of Science:
- Neuroimaging
- Stroke Research
- Medical Physics
Background:
- Mapping high oxygen extraction fraction (OEF) is crucial for identifying at-risk tissue in acute stroke.
- T2*-weighted MRI, sensitive to deoxyhemoglobin, was proposed as a potential marker for high OEF.
Purpose of the Study:
- To evaluate the sensitivity of T2*-weighted MRI to high OEF in acute stroke patients.
Main Methods:
- Compared pre-contrast T2*-weighted MRI scans with quantitative positron emission tomography (PET) in 5 acute stroke patients.
- Analyzed T2* signal and OEF in voxels with significantly high OEF, 7-21 hours post-stroke onset.
Main Results:
- All patients exhibited elevated OEF.
- No significant correlation was observed between OEF and T2*-weighted signal, neither within individual subjects nor across the group.
Conclusions:
- The implemented T2*-weighted MRI technique did not demonstrate sensitivity to high OEF in acute stroke.
- Further research may be needed to explore alternative MRI sequences or methods for OEF assessment in stroke.
