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Updated: Jun 21, 2026
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
Published on: September 20, 2015
T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke
M L Donswijk1, P S Jones, J V Guadagno
1Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Background:
Mapping high oxygen extraction fraction (OEF) in acute stroke is of considerable interest to depict the at-risk tissue. Being sensitive to deoxyhemoglobin, T2*-weighted MRI has been suggested as a potential marker of high OEF.
Methods:
We compared T2*-weighted images from pre-contrast arrival perfusion scans against quantitative positron emission tomography in 5 patients studied 7-21 h after onset of carotid territory stroke. OEF and T2* signal were obtained in the voxels with significantly high OEF.
Results:
All patients showed increased OEF. No significant relationship between OEF and T2*-weighted signal was found either within or between subjects.
Conclusion:
We found no indication that T2*-weighted MRI in the way implemented in this investigation was sensitive to high OEF in acute stroke.
