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An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
Published on: December 1, 2017
Influenza immunization in pregnancy
Noni E MacDonald1, Laura E Riley, M C Steinhoff
1From the Division Pediatric Infectious Diseases, Dalhousie University, IWK Health Center, Halifax, Nova Scotia, Canada; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts; and Children's Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Abstract:
Among healthy persons, two groups are notable for increased risk of serious illness and hospitalization with influenza infection: healthy women in pregnancy and their healthy infants (aged 0 to 6 months). Inactivated influenza vaccine has been used in pregnant women since the 1960s in both the United States and Canada; however, currently, only 15% of pregnant women receive the vaccine. A randomized, controlled trial has shown influenza immunization of pregnant women reduced influenza-like illness by more than 30% in both the mothers and the infants and reduced laboratory-proven influenza infections in 0- to 6-month-old infants by 63%. Physicians caring for pregnant women should be aware of the risks of influenza and of the availability of an effective and cost-saving intervention.
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