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Published on: August 4, 2019
TP53 Arg72Pro polymorphism and lung cancer risk: a meta-analysis
Lili Yan1, Deqiang Zhang, Chengwen Chen
1State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Department of Respiratory Disease, Shanghai Chest Hospital, Shanghai 200433, China.
International Journal of Cancer
|July 23, 2009
Summary
The TP53 Arg72Pro polymorphism (G12139C) is associated with increased lung cancer risk in Asians and overall populations, particularly for adenocarcinoma and stage I lung cancer. No link was found in Caucasians or with smoking.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The TP53 Arg72Pro polymorphism (G12139C) is a common genetic variation.
- Its association with lung cancer risk remains controversial, necessitating further investigation.
Purpose of the Study:
- To conduct a meta-analysis to clarify the association between the TP53 Arg72Pro polymorphism (G12139C) and lung cancer risk.
- To explore potential ethnic and cancer-specific differences in this association.
Main Methods:
- A meta-analysis was performed combining data from multiple studies.
- Statistical analyses included overall comparisons, ethnic-specific analyses (Caucasians, Asians), and subgroup analyses by cancer type and stage.
- Genetic models (recessive, dominant, homozygote comparison) were applied.
Main Results:
- No significant association was found between the 12139C allele and lung cancer risk in Caucasians.
- A significant association was observed in the overall population (OR=1.08) and in Asians (OR=1.14), especially under recessive models.
- The 12139C allele was linked to increased lung adenocarcinoma risk (OR=1.11) and stage I lung cancer (OR=1.48 under dominant model).
- No association was found with smoking status.
Conclusions:
- The TP53 Arg72Pro polymorphism (12139C allele) may increase lung cancer risk, particularly in Asians and for lung adenocarcinoma.
- The association appears significant in early-stage lung cancer (Stage I).
- Further research is needed to elucidate the role of this polymorphism, considering interactions with cancer stage and other factors.
