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Updated: Jun 21, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[Studies on flavonoids and amides from herbs of Solanum lyratum]
Yan Ren1, Li Shen, Shengjun Dai
1School of Pharmaceutical Science, Yantai University, Yantai 264005, China.
Objective:
To investigate the chemical constituents in 95% alcohol extract of Solanum lyratum.
Method:
The compounds were isolated by column chromatography over silica gel, and purified by Sephadex LH-20 column chromatography and preparative TLC. The structures were elucidated on the basis of physicochemical properties and spectral data.
Result:
Eleven compounds were isolated and identified as: formononetin (1), vanillic acid (2), genistein (3), apigenin (4), N-trans-feruloyltyramine (5), N-p-coumaroyltyramine (6), daidzein (7), caffeic aicd (8), protocatechuic acid (9), daidzin (10), and N-trans-feruloyl-3-methyldopamine (11).
Conclusion:
For the first time, compound 11 was separated from Solanaceae plant, and compounds 5 and 10 were isolated from Solanum, and compounds 1, 3, 4, 7 and 9 were obtained from this plant for the first time.
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