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Roller compaction: Application of an in-gap ribbon porosity calculation for the optimization of downstream granule
John F Gamble1, Michael Tobyn, Andrew B Dennis
1Biopharmaceutics R&D, Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, England.
Abstract:
This paper reports the use of an in-gap ribbon porosity calculation for the optimisation of roller compaction ribbon parameters in order to control downstream granule and tablet properties for a typical pharmaceutical formulation. The study demonstrates the effect of changes to roll speed and roll gap on the relative level of ribbon compaction for ribbons with equivalent in-gap porosities. It is demonstrated that in-gap ribbon porosity can be applied to enable optimization of the downstream granule processability characteristics for a typical pharmaceutical formulation and an understanding of the control space of a roller compaction process.
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