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Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

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Developing a Rat Model for Bipolar Disorder
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Remission from mania is associated with a decrease in amygdala activation during motor response inhibition.

Arthur Kaladjian1, Régine Jeanningros, Jean-Michel Azorin

  • 1Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193 CNRS - Université de la Méditerranée, 31, chemin Joseph Aiguier, 13402 Marseille cedex 20, France. arthur.kaladjian@univmed.fr

Bipolar Disorders
|July 24, 2009
PubMed
Summary
This summary is machine-generated.

Bipolar disorder (BD) remission is linked to decreased left amygdala activation during motor inhibition tasks. Longitudinal neuroimaging reveals this critical brain change, highlighting its relevance for understanding mood shifts in BD.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Bipolar disorder (BD) is characterized by mood states of mania and depression.
  • Neuroimaging studies indicate functional brain abnormalities in BD during both manic and remitted states.
  • However, the specific brain network differences between mania and remission remain unclear.

Purpose of the Study:

  • To investigate longitudinal functional brain changes associated with symptomatic remission from mania in bipolar disorder.
  • To examine alterations in the brain network underlying motor response inhibition during mood state transitions in BD.
  • To identify specific brain regions exhibiting differential activation changes between manic and remitted states in BD patients compared to healthy controls.

Main Methods:

  • Event-related functional magnetic resonance imaging (fMRI) was employed.
  • Ten BD patients and ten healthy subjects underwent two fMRI scans while performing a Go/NoGo task.
  • BD patients were scanned during a manic state and again during symptomatic remission; healthy subjects were scanned twice over a similar time interval.

Main Results:

  • A significant time-dependent change in activation was observed in the left amygdala, differentiating BD patients from healthy subjects.
  • This difference was attributed to a decrease in left amygdala activation in BD patients from the manic state to the remitted state.
  • No other brain regions showed significant time-by-group interactions.

Conclusions:

  • A reduction in left amygdala responsiveness is a key neurofunctional modification associated with remission from mania in bipolar disorder.
  • This finding underscores the importance of longitudinal neuroimaging studies for understanding neurofunctional changes related to mood state fluctuations in BD.
  • The left amygdala's role in emotional regulation may be critical in the transition from mania to remission.