Intergenogroup recombinant sapovirus in Japan, 2007-2008

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Wisoot Chanit1, Aksara Thongprachum, Pattara Khamrin

  • 1The University of Tokyo, Tokyo, Japan.

Emerging Infectious Diseases
|July 24, 2009
PubMed

Insights

Sapovirus (SaV) caused gastroenteritis in 4% of Japanese infants and children studied. The most common strains were intergenogroup recombinant sapoviruses (GII/GIV), indicating significant viral diversity.

Area of Science:

  • Virology
  • Pediatric Gastroenterology
  • Public Health

Background:

  • Gastroenteritis remains a significant health concern in infants and children worldwide.
  • Sapovirus (SaV) is an important etiological agent of gastroenteritis, particularly in young children.
  • Limited data exists on the prevalence and genetic diversity of SaV in Japan.

Purpose of the Study:

  • To determine the incidence of sapovirus-associated gastroenteritis in Japanese infants and children.
  • To characterize the genetic diversity of detected Sapovirus strains.

Main Methods:

  • Fecal specimens from 477 infants and children were collected between 2007 and 2008.
  • Sapovirus detection was performed using molecular methods.
  • Genotyping was conducted to characterize the diversity of SaV strains.

Main Results:

  • Sapovirus was detected in 19 (4%) of the 477 fecal specimens.
  • The predominant genogroup identified was GII/GIV, accounting for 79% (15 cases) of SaV-positive samples.
  • These GII/GIV strains were characterized as intergenogroup recombinant Sapoviruses.

Conclusions:

  • Sapovirus is a relevant cause of gastroenteritis in Japanese children.
  • Intergenogroup recombinant strains, particularly GII/GIV, are the dominant circulating Sapovirus types in this population.
  • Further surveillance is needed to understand the long-term impact and evolution of Sapovirus strains.

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