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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...

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Related Experiment Video

Updated: Jun 21, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

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Published on: May 31, 2021

Contact urticaria to raw potato.

Z Martínez de Lagrán, F J Ortiz de Frutos, M González de Arribas

    Dermatology Online Journal
    |July 24, 2009
    PubMed
    Summary

    Adverse reactions to raw potatoes, though uncommon, can cause allergic contact urticaria in adults. This case highlights skin reactions from touching raw potatoes, confirmed by prick testing.

    Area of Science:

    • Allergen immunology
    • Dermatology
    • Food allergy

    Background:

    • Potatoes are a global dietary staple, yet adverse reactions are typically linked to ingestion, primarily in children.
    • Immediate hypersensitivity reactions to raw potato contact are less common but documented in adults.

    Observation:

    • This report details a case of non-occupational allergic contact urticaria triggered by direct contact with raw potato.
    • The patient presented with symptoms indicative of an allergic reaction upon skin exposure to uncooked potato.

    Findings:

    • The allergic contact urticaria was confirmed through diagnostic prick testing, establishing a clear link between raw potato and the patient's reaction.
    • Prick testing successfully identified raw potato as the allergen responsible for the observed urticarial response.

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    Implications:

    • This case underscores the potential for raw potato to act as a contact allergen, leading to urticaria and other immediate hypersensitivity reactions in susceptible adults.
    • Healthcare providers should consider raw potato allergy in the differential diagnosis of unexplained contact urticaria, especially in non-occupational settings.
    • Further investigation into the prevalence and mechanisms of raw potato allergy is warranted.