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Related Concept Videos

Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...

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Diagnosis of Ecto- and Endoparasites in Laboratory Rats and Mice
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Published on: September 6, 2011

Cat scratch disease: a diagnostic conundrum.

C Scott1, A Azwa, C Cohen

  • 1Department of Sexual Health & HIV Medicine, St Stephens Centre, Chelsea & Westminster Hospital, 369 Fulham Road, London, UK. christopher.scott@chelwest.nhs.uk

International Journal of STD & AIDS
|July 24, 2009
PubMed
Summary
This summary is machine-generated.

Cat scratch disease (CSD) can mimic Lymphogranuloma venereum (LGV) in patients with inguinal lymphadenopathy. Early diagnosis can be challenging, as serology may initially suggest LGV before confirming CSD.

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Last Updated: Jun 21, 2026

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Lymphadenopathy is a common clinical presentation requiring differential diagnosis.
  • Lymphogranuloma venereum (LGV) and Cat Scratch Disease (CSD) are infectious causes of lymphadenopathy.
  • Distinguishing between LGV and CSD can be clinically challenging.

Observation:

  • A patient presented with inguinal lymphadenopathy and microabscess formation on lymph node histology.
  • Initial clinical and serological findings suggested early LGV.
  • The patient reported no history of animal exposure.

Findings:

  • Convalescent serology ultimately supported a diagnosis of CSD caused by Bartonella henselae.
  • Histological findings of microabscesses were consistent with both LGV and CSD.
  • The absence of reported animal exposure complicated the initial diagnostic pathway.

Implications:

  • Bartonella henselae infection should be considered in the differential diagnosis of regional lymphadenopathy, especially in patients suspected of LGV.
  • This case highlights the importance of comprehensive serological testing in diagnosing CSD.
  • Clinicians should maintain a high index of suspicion for CSD even in the absence of a clear animal exposure history.