Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ascorbic acid and carnitine biosynthesis.

C J Rebouche1

  • 1Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242.

The American Journal of Clinical Nutrition
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of long-term valproic acid administration on the efficiency of carnitine reabsorption in humans.

Metabolism: clinical and experimental·1999
Same author

Carnitine metabolism and its regulation in microorganisms and mammals.

Annual review of nutrition·1998
Same author

Renal handling of carnitine in experimental vitamin C deficiency.

Metabolism: clinical and experimental·1995
Same author

The ability of guinea pigs to synthesize carnitine at a normal rate from epsilon-N-trimethyllysine or gamma-butyrobetaine in vivo is not compromised by experimental vitamin C deficiency.

Metabolism: clinical and experimental·1995
Same author

Effect of dietary macronutrient content on carnitine excretion and efficiency of carnitine reabsorption.

The American journal of clinical nutrition·1993
Same author

Renal adaptation to dietary carnitine in humans.

The American journal of clinical nutrition·1993
Same journal

High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

The American journal of clinical nutrition·2026
Same journal

Reply to Wu et al.: "Nitrate and nitrite food composition database: an update and extensive deep dive".

The American journal of clinical nutrition·2026
Same journal

Reframing Basic Experimental Studies in Humans-Implications for Nutrition Science.

The American journal of clinical nutrition·2026
Same journal

Inconvenient for the investigator but convenient for science: trial registration in The American Journal of Clinical Nutrition.

The American journal of clinical nutrition·2026
Same journal

Energy requirements revisited: why the factorial model still matters.

The American journal of clinical nutrition·2026
Same journal

Letter to the Editor: Temporal eating pattern classification should be separated from model attribution and reporting artifacts.

The American journal of clinical nutrition·2026
See all related articles

Vitamin C (ascorbic acid) is crucial for carnitine biosynthesis, impacting enzymes involved in its production. Deficiency may lead to carnitine levels that contribute to scurvy symptoms like fatigue.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Human Physiology

Background:

  • Scurvy symptoms, such as fatigue and weakness, have been linked to carnitine deficiency.
  • Ascorbic acid (vitamin C) acts as a cofactor in key enzymatic reactions of carnitine biosynthesis.

Purpose of the Study:

  • To investigate the role of ascorbic acid in carnitine biosynthesis.
  • To determine the impact of vitamin C deficiency on enzymes involved in carnitine production.

Main Methods:

  • Studies involved enzyme preparations and perfused liver in vitro.
  • Experiments were conducted using scorbutic guinea pigs in vivo.

Main Results:

  • Ascorbic acid deficiency in guinea pigs decreased hepatic gamma-butyrobetaine hydroxylase activity.

Related Experiment Videos

  • Renal epsilon-N-trimethyllysine hydroxylase activity was reduced, but hepatic activity was unaffected by ascorbic acid deficiency when exogenous substrates were supplied.
  • Carnitine concentrations were variably reduced in some tissues of scorbutic guinea pigs.

    • Conclusions:

    • Ascorbic acid plays a role in carnitine biosynthesis.
    • While the overall impact on endogenous synthesis remains unclear, evidence supports ascorbic acid's participation in the carnitine pathway.