Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A role for ascorbic acid in copper transport.

E D Harris1, S S Percival

  • 1Department of Biochemistry and Biophysics, Texas A&M University, College Station 77843-2128.

The American Journal of Clinical Nutrition
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Words, dictionaries, poems, and pictures.

The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2003
Same author

Effects of residual and reapplied biosolids on performance and mineral status of grazing beef steers.

Journal of animal science·2002
Same author

One hundred ... and counting!

The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2002
Same author

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.

Genome biology·2001
Same author

Making the best of a disturbed mind.

The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2001
Same author

The bone and joint decade: a catalyst for progress.

Arthritis and rheumatism·2001
Same journal

Effect of fortified Bovine colostrum on linear growth of children aged 9-36 months: a community-based three-arm randomized controlled trial in urban slums of Belagavi city, India.

The American journal of clinical nutrition·2026
Same journal

Nourishing Collaboration: Interdisciplinary Nutrition Education for Health Care Professionals.

The American journal of clinical nutrition·2026
Same journal

Associations of red blood cell fatty acids with personality traits: 10-year follow-up in the Kibbutzim Family Study.

The American journal of clinical nutrition·2026
Same journal

Corrigendum to: Vitamin D status and breast cancer in Saudi Arabian women: case-control study [Am J Clin Nutr 98 (2013) 105-110].

The American journal of clinical nutrition·2026
Same journal

High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

The American journal of clinical nutrition·2026
Same journal

Reply to Wu et al.: "Nitrate and nitrite food composition database: an update and extensive deep dive".

The American journal of clinical nutrition·2026
See all related articles

Vitamin C (ascorbate) influences copper metabolism by affecting its absorption and cellular transport. It may play both positive and negative regulatory roles in copper utilization within the body.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Copper deficiency can induce scurvy-like symptoms, suggesting a link between copper and vitamin C.
  • Vitamin C (ascorbate) is known to affect copper absorption and cellular uptake.
  • Ceruloplasmin, a key serum copper protein, is implicated in ascorbate's role.

Purpose of the Study:

  • To investigate the multifaceted role of vitamin C (ascorbate) in copper metabolism.
  • To elucidate the mechanisms by which ascorbate influences copper absorption and intracellular transport.
  • To explore ascorbate's regulatory functions in copper homeostasis.

Main Methods:

  • Review of existing literature on vitamin C and copper interactions.
  • Analysis of experimental data on copper deficiency and scurvy-like symptoms.

Related Experiment Videos

  • Characterization of ascorbate's effects on copper transfer and binding.

    • Main Results:

    • Ascorbate antagonizes intestinal copper absorption.
    • Ascorbate facilitates post-absorptive copper ion transfer across cell membranes, interacting with ceruloplasmin.
    • High ascorbate levels inhibit intracellular copper binding to Cu,Zn superoxide dismutase.

    Conclusions:

    • Vitamin C (ascorbate) exhibits complex regulatory effects on copper metabolism.
    • Ascorbate influences copper at multiple stages, from absorption to intracellular utilization.
    • Further research is needed to fully understand the mechanisms of ascorbate's positive and negative regulatory roles in copper homeostasis.