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Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Inflammation01:38

Inflammation

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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

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Related Experiment Video

Updated: Jun 21, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Circulating oxidized LDL: a biomarker and a pathogenic factor.

Yasushi Ishigaki1, Yoshitomo Oka, Hideki Katagiri

  • 1Division of Molecular Metabolism and Diabetes, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai 980-8575, Japan.

Current Opinion in Lipidology
|July 24, 2009
PubMed
Summary
This summary is machine-generated.

Circulating oxidized LDL (oxLDL) is elevated in atherosclerosis and metabolic disorders. Reducing oxLDL levels offers a promising therapeutic strategy for preventing atherosclerosis progression.

Related Experiment Videos

Last Updated: Jun 21, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

  • Cardiovascular Research
  • Atherosclerosis Pathogenesis
  • Lipid Metabolism

Background:

  • Oxidized LDL (oxLDL) plays a role in atherogenesis within the vascular wall.
  • The significance of circulating oxLDL in human and murine models is increasingly recognized.
  • Measuring circulating oxLDL has advanced, providing new insights into its importance.

Purpose of the Study:

  • To review the significance of circulating oxidized LDL (oxLDL) in atherogenic processes.
  • To highlight the growing evidence for oxLDL's role in cardiovascular disease.
  • To explore potential therapeutic strategies targeting circulating oxLDL.

Main Methods:

  • Review of recent studies on oxLDL measurement and its clinical relevance.
  • Analysis of in-vitro studies on oxLDL's effect on cellular pathways.
  • Examination of animal models demonstrating the impact of modulating oxLDL levels.

Main Results:

  • Elevated circulating oxLDL is observed in advanced atherosclerosis (coronary heart disease, ischemic stroke) and metabolic disorders (diabetes, obesity).
  • In-vitro oxLDL exposure increases mononuclear cell NF-κB activity, indicating a role in oxidative stress.
  • Animal studies show that blocking modified LDL uptake or reducing circulating oxLDL prevents atherosclerotic progression.

Conclusions:

  • Circulating oxLDL is a key factor in atherosclerotic pathogenesis.
  • Targeting oxLDL removal from circulation presents a promising therapeutic avenue for atherosclerosis.