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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Breaking the chains: structure and function of the deubiquitinases

David Komander1, Michael J Clague, Sylvie Urbé

  • 1Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK. dk@mrc-lmb.cam.ac.uk

Nature Reviews. Molecular Cell Biology
|July 24, 2009
PubMed
Summary

Deubiquitinases (DUBs) are enzymes that remove ubiquitin, a key protein tag. These diverse enzymes are highly regulated, offering potential as novel therapeutic targets for various diseases.

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