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Updated: Jun 21, 2026

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches
Published on: June 25, 2020
Oral lichen planus and chronic junctional stomatitis: differences in lymphocyte subpopulations
A Ahmed Haji Omar1, Jarkko Hietanen, Mia Kero
1Institute of Dentistry, University of Helsinki, Helsinki, Finland.
Objective:
Oral lichen planus (OLP) is an oral counterpart or oral manifestation of the common skin disease lichen planus. Chronic junctional stomatitis (CJS) is a relatively unknown condition characterized by a stromal lymphocyte infiltrate, which is also a diagnostic feature of OLP. The differential diagnosis of OLP and CJS is unclear and they have been suggested to represent variants of the same disease.
Material And Methods:
To investigate possible differences in lymphocyte (sub)populations between these two conditions, we immunostained 10 OLP and 10 CJS specimens for CD1-a, and the lymphocyte markers, CD3, CD4, CD5, CD8, and CD20. We scored the staining results by a four-step grading system and used the Fisher exact test to analyze them statistically.
Results:
The proportional amount of (CD20 positive) B lymphocytes was higher in CJS than in OLP and the predominance of CD4 positive T lymphocytes over CD8 positive T lymphocytes was stronger in OLP than in CJS. The differences were statistically significant.
Conclusion:
The results reflect differences in the lymphatic infiltrate between OLP and CJS. Their significance needs further investigation.
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