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Maternal serum adiponectin concentration in gestational diabetes
Sedigheh Soheilykhah1, Mohammad Mohammadi, Mahdieh Mojibian
1Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. s_soheilykhah@yahoo.com
Summary
Serum adiponectin levels are significantly lower in women with gestational diabetes mellitus compared to healthy pregnant women. This finding highlights adiponectin
Area of Science:
- Endocrinology
- Metabolic Disorders
- Maternal-Fetal Medicine
Background:
- Gestational diabetes mellitus (GDM) is characterized by insulin resistance.
- Adiponectin, an insulin-sensitizing protein, plays a role in glucose metabolism.
- Understanding adiponectin's role in GDM is crucial for managing pregnancy complications.
Purpose of the Study:
- To compare serum adiponectin levels between pregnant women with GDM and healthy controls.
- To investigate the relationship between adiponectin, insulin resistance, and clinical factors in GDM.
Main Methods:
- A comparative study involving 29 women with GDM, 26 with impaired glucose tolerance, and 27 healthy pregnant women.
- Participants were matched for gestational age, age, and pre-pregnancy BMI.
- Serum adiponectin, insulin, and insulin resistance (HOMA index) were measured at 28 weeks gestation.
Main Results:
- Serum adiponectin levels were significantly lower in women with GDM (6379.31 ng/ml) compared to impaired glucose tolerance (7384.61 ng/ml) and control groups (7962.96 ng/ml) (p=0.02).
- Insulin and HOMA index were higher in the GDM group, though not statistically significant (p>0.05).
- A significant negative correlation was found between adiponectin and pre-pregnancy BMI in GDM patients (r=-0.531, p=0.013).
Conclusions:
- Serum adiponectin levels are significantly reduced in women with gestational diabetes mellitus.
- Lower adiponectin may contribute to the insulin resistance observed in GDM.
- Adiponectin levels did not show a significant correlation with neonatal birth weight.
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