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Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

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Published on: August 12, 2014

Recent developments in carbohydrate-decorated targeted drug/gene delivery.

Hailong Zhang¹, Yong Ma, Xue-Long Sun

¹Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115, USA.

Medicinal Research Reviews

|July 24, 2009

Summary

Carbohydrates are emerging as powerful targeting ligands for drug and gene delivery systems. Their biocompatibility and specific recognition properties enhance therapeutic efficiency and reduce toxicity.

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Area of Science:

Biomedical engineering
Pharmaceutical sciences
Glycoscience

Background:

Targeted drug and gene delivery aims to maximize therapeutic efficacy and minimize systemic toxicity.
Current strategies involve loading carriers with drugs/genes and using targeting ligands for specific cell/tissue recognition.

Purpose of the Study:

To review the recent advancements in carbohydrate-decorated systems for targeted drug and gene delivery.
To highlight the potential of carbohydrates as targeting ligands in pharmaceutical applications.

Main Methods:

Literature review of studies on carbohydrate-based drug/gene delivery systems.
Analysis of the role of glycobiology, glycotechnology, and glycomics in advancing targeted delivery.

Main Results:

Carbohydrates exhibit excellent biocompatibility and specific receptor recognition capabilities.
These properties make them suitable as targeting ligands for drug and gene carriers.
Carbohydrate decoration enhances the specificity and efficiency of targeted delivery systems.

Conclusions:

Carbohydrates represent a promising class of molecules for developing advanced targeted drug and gene delivery platforms.
Their unique biological properties offer significant advantages over conventional targeting strategies.
Further research in this area holds potential for novel therapeutic applications.