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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
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IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas

Cathrine Hoyo1, Joellen M Schildkraut, Susan K Murphy

  • 1Department of Community and Family Medicine, Duke University, Durham, NC 27710, USA. hoyo0001@mc.duke.edu

International Journal of Cancer
|July 24, 2009
PubMed

Insights

Genetic variants in the mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) gene may increase the risk of esophageal-gastric cardia adenocarcinoma and noncardia gastric cancer, particularly in white males. Further research is needed to confirm these associations.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a tumor suppressor gene involved in regulating insulin-like growth factor-2 (IGF2) bioavailability.
  • Genetic variations within M6P/IGF2R may influence cancer susceptibility.

Purpose of the Study:

  • To investigate the association between common nonsynonymous genetic variants in M6P/IGF2R and the risk of esophageal and gastric cancers.
  • To explore potential modifying effects of NSAID use and smoking on these associations.

Main Methods:

  • A population-based study involving 197 controls and 182 cancer cases (esophageal-gastric cardia adenocarcinoma, noncardia gastric adenocarcinoma, esophageal squamous cell carcinoma).
  • Genotyping for M6P/IGF2R variants c.901C > G (exon 6) and c.5002G > A (exon 34).
  • Statistical analysis including odds ratios (ORs) and confidence intervals (CIs), with subgroup analyses.

Main Results:

  • Carrying at least one c.901C > G allele was associated with increased risk of esophageal-gastric cardia adenocarcinoma (OR = 1.9) and noncardia gastric cancer (OR = 2.5) in white males.
  • These associations were stronger among non-NSAID users and cigarette smokers.
  • No significant association was found for the c.5002G > A variant with esophageal-gastric cardia adenocarcinoma.

Conclusions:

  • Nonsynonymous polymorphisms in M6P/IGF2R, specifically c.901C > G, may contribute to the risk of esophageal-gastric cardia adenocarcinoma and noncardia gastric cancer.
  • Lifestyle factors like NSAID use and smoking may modify the risk associated with M6P/IGF2R variants.
  • Larger studies are warranted to validate these findings.

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