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Immuno-histochemical expression of p53 protein and iNOS in odontogenic cysts
Sopee Poomsawat1, Jirapa Punyasingh, Paisarn Vejchapipat
1Department of Oral Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. spoomsawat@yahoo.com
Objective:
The present study investigated the expression of p53 protein and iNOS in odontogenic keratocysts (OKCs), dentigerous cysts (DCs) and radicular cysts (RCs) and determined the correlation of these 2 proteins within each cyst type.
Material And Method:
p53 and iNOS in epithelial lining cells were analyzed in 20 OKCs, 20 DCs and 20 RCs using immuno-histochemistry. The percentage of positive cells was assessed and presented as mean +/-SD. The correlation between the expressions of these 2 proteins in each cyst was carried out using Spearman correlation analysis.
Results:
p53 was found in 95% of OKCs, 50% of DCs and 65% of RCs. p53-positive cells in OKCs (12.2 +/- 8.8%) were significantly higher than those in DCs (1.4 +/- 3.2%) and RCs (1.3 +/- 2.4%). iNOS was found in all examined lesions. Statistically, iNOS-positive cells in RCs (86.9 +/- 9.9%) were lower than those in OKCs (94.8 +/- 3.5%) and DCs (96.1 +/- 4.4%). No correlation between the expression of p53 and iNOS was found in each cyst.
Conclusion:
p53 was over expressed in OKCs compared with other lesions. RCs showed the lowest expression of iNOS.
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