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Tausalarin C: a new bioactive marine sponge-derived nitrogenous bismacrolide
Ashgan Bishara1, Amira Rudi, Israel Goldberg
1School of Chemistry, Tel AViV UniVersity, Ramat AViV 69978, Israel.
Abstract:
A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.
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