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Self-organization of synthetic cholesteryl oligoethyleneglycol glycosides in water
Vincent Faivre1, Pierre-Louis Bardonnet, Paul Boullanger
1Laboratoire de Physico-Chimie des Systèmes Polyphasés, UMR CNRS 8612-IFR 141, Université Paris-Sud, 5 rue J.B. Clement, 92296 Châtenay-Malabry, France. vincent.faivre@u-psud.fr
Abstract:
Lectin-sugar recognition systems are of interest in the pharmaceutical field, especially for the development of drug carriers, tailored for selective delivery. This paper deals with the anhydrous and aqueous self-organization properties of a synthetic cholesteryl oligoethyleneglycol glycoside with the aim of their incorporation in liposomes. Successive phases (lamellar, R3m, Im3m, micelles) have been described depending on water content and temperature. As a result of the presence of sugar residues and their hydration ability, this glycolipid shows a large range of packing parameter with increasing water content. However, because of oligoethyleneglycol spacer, a slight dehydration has been observed with increasing temperature from 20 to 60 degrees C.
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