Related Experiment Video
Updated: Jun 21, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Effusive constrictive pericarditis
Rajeev Garg1, Avneet Singh, Anand Chockalingam
1Department of Internal Medicine, Division of Cardiology, University of Missouri-Columbia, Columbia, MO, USA.
Insights
Effusive constrictive pericarditis (ECP) may be reversible. Steroids and colchicine offer effective non-surgical treatment options for ECP, potentially avoiding invasive surgery.
Area of Science:
- Cardiology
- Internal Medicine
- Pericardial Diseases
Background:
- Effusive constrictive pericarditis (ECP) is a rare condition where symptoms persist despite pericardial effusion drainage.
- Surgical pericardiectomy is the traditional treatment but involves significant risks.
- Recent evidence suggests potential reversibility in some ECP cases.
Observation:
- Two patients with ECP were successfully treated non-surgically.
- One patient received steroids, and the other received colchicine.
- Both patients experienced resolution of symptoms, avoiding surgery.
Findings:
- Steroids and colchicine represent viable non-surgical therapeutic options for ECP.
- These treatments can obviate the need for extensive pericardial stripping.
- A subset of ECP patients may exhibit reversible pericardial pathology.
Implications:
- Non-surgical management with steroids or colchicine should be considered for ECP.
- Further research into the role of colchicine in reversible pericarditis is warranted.
- This approach may reduce morbidity and mortality associated with ECP treatment.
Abstract:
Effusive constrictive pericarditis (ECP) is a relatively infrequent pericardial condition. The diagnosis is typically made when symptoms and right heart pressure elevation persist despite drainage of pericardial effusion. Visceral and parietal pericardial stripping is an extensive procedure with significant morbidity and mortality but is widely considered the only effective treatment. Recent studies suggest that up to 10% of constriction may be reversible, and a newer series has reported spontaneous complete resolution of symptoms in a subset of ECP patients. In this review, the authors describe 2 patients with ECP who were managed successfully with steroids and colchicine, respectively, thus obviating the need for surgery. The authors also review the current understanding of this reversible pericardial pathology and explore the possible role for colchicine in treating this condition.
Related Concept Videos
Pericarditis I: Introduction
Pericarditis II: Clinical Features and Diagnostic Tests
Pericarditis III: Medical Management
Cardiomyopathy IV: Restrictive Cardiomyopathy
Rheumatic Heart Disease I: Introduction
Pericarditis IV: Nursing Management

