Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence of type 1 diabetes in Navarra, 2009-2020. Evidence of a stabilization.

Endocrinologia, diabetes y nutricion·2023
Same author

Incidence and temporal trends of childhood type 1 diabetes between 1975 and 2012 in Navarre (Spain).

Gaceta sanitaria·2014
Same author

An unusual association: pheochromocytoma on an atrophied adrenal gland due to addison's disease.

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion·2012
Same author

[Asymptomatic hypomagnesemic hypoparathyroidism induced by pantoprazol].

Medicina clinica·2011
Same author

[Diabetes insipidus as an atypical presentation of lung adenocarcinoma].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion·2010
Same author

Prognostic value of thyroglobulin serum levels and 131I whole-body scan after initial treatment of low-risk differentiated thyroid cancer.

Thyroid : official journal of the American Thyroid Association·2004

Related Experiment Video

Updated: Jun 21, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

[Cushing's syndrome: special issues].

María José Goñi Iriarte1

  • 1Servicio de Endocrinología, Hospital de Navarra, Pamplona, Navarra, Spain. mgoniiri@cfnavarra.es

Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion
|July 25, 2009
PubMed
Summary

This review covers adrenal hyperplasia and Cushing's syndrome, differentiating subclinical and preclinical forms. It highlights the rarity of Cushing's syndrome in children and pregnancy, with specific causes and incidence rates.

Area of Science:

  • Endocrinology
  • Adrenal Gland Disorders
  • Hormone Imbalance

Background:

  • Reviews adrenal hyperplasia, including bilateral macronodular and micronodular types.
  • Discusses subclinical Cushing's syndrome, distinguishing it from preclinical forms.
  • Addresses the low incidence of Cushing's syndrome in pediatric populations and pregnancy.

Purpose of the Study:

  • To provide a comprehensive overview of adrenal hyperplasia and Cushing's syndrome.
  • To clarify diagnostic distinctions between subclinical and preclinical Cushing's syndrome.
  • To summarize current knowledge on pediatric and pregnancy-related Cushing's syndrome.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of diagnostic criteria for adrenal hyperplasia and Cushing's syndrome.

More Related Videos

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Related Experiment Videos

Last Updated: Jun 21, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

  • Examination of epidemiological data for specific patient groups.

    • Main Results:

    • Corticotrophin (ACTH)-independent bilateral macronodular adrenal hyperplasia involves aberrant adrenal receptors.
    • Subclinical Cushing's syndrome is characterized by autonomous cortisol production without overt symptoms.
    • ACTH-dependent Cushing's disease is the primary cause in children over 7 years old.

    Conclusions:

    • Accurate differentiation of subclinical Cushing's syndrome is crucial for patient management.
    • Cushing's syndrome is rare in children, with specific etiological factors.
    • Pregnancy with Cushing's syndrome is uncommon but documented, requiring careful monitoring.