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Related Experiment Video

Updated: Jun 21, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Environmentally responsive peptides as anticancer drug carriers.

Suhaas Aluri¹, Siti M Janib, J Andrew Mackay

¹Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90033-9121, USA.

Advanced Drug Delivery Reviews

|July 25, 2009

Summary

This summary is machine-generated.

Peptides can be engineered to target cancer's unique tumor microenvironment signals. This approach enhances chemotherapy efficacy by leveraging peptides' specific interactions and responsive properties for targeted drug delivery.

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Area of Science:

Biotechnology
Oncology
Materials Science

Background:

The tumor microenvironment (TME) presents unique signals that can be leveraged to enhance chemotherapy.
Polypeptides (peptides) offer versatile properties for exploiting TME cues.

Purpose of the Study:

To review how peptides can be utilized to target and deliver therapeutics within the tumor microenvironment.
To explore the potential of peptide-based nanocarriers for cancer therapy.

Main Methods:

Review of existing literature on peptide properties and TME signaling.
Analysis of peptide interactions, phase behaviors, self-assembly, biodegradation, and biosynthesis.
Identification of peptides that target specific TME characteristics.

Main Results:

Peptides offer specific biological interactions and environmentally responsive behaviors.
Peptides facilitate controlled self-assembly and biodegradation pathways.
Peptides can be synthesized into functional polymers for targeted delivery.

Conclusions:

Peptides are promising functional units for developing cancer-targeted nanocarriers.
Exploiting TME physiology with peptides can improve the efficacy of chemotherapeutics.
Peptide-based strategies offer a unique platform for precision oncology.